Didn't stop fleas after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

977 reports to the FDA describe didn't stop fleas in dogs given Lufenuron + Milbemycin Oxime. That is 3.8% of all reports for this medicine, compared with 6.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

977Reports

9.9%Marked serious

4.7%Recovered

0.2%Died or euthanised

15 daysTypical onset

How soon it started

Same day

61 19%

1–2 days

14 4.3%

3–7 days

36 11%

1–4 weeks

111 34%

Over a month

100 31%

How the animals did

Recovered

42 4.3%

Recovered with lasting effects

4 0.4%

Still unwell when reported

259 27%

Died

1 0.1%

Euthanised

1 0.1%

Not known

670 69%

Problems reported at the same time

Itching

93 9.5%

Didn't work as expected

52 5.3%

21 2.1%

19 1.9%

16 1.6%

14 1.4%

13 1.3%

13 1.3%

Age of the animals

Under 1 year

1–3 years

201

4–7 years

263

8–11 years

169

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause didn't stop fleas in dogs?: 977 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 15 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't stop fleas with similar medicines

Didn't stop fleas after Spinosad (Comfortis) 13,280 reports · 23% of its reports
Didn't stop fleas after Imidacloprid + Moxidectin (Advantage Multi) 1,444 reports · 11% of its reports
Didn't stop fleas after Nitenpyram (Capstar) 6,142 reports · 57% of its reports
Didn't stop fleas after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 498 reports · 5.0% of its reports
Didn't stop fleas after Fipronil + S-methoprene (Frontline Plus) 576 reports · 19% of its reports
Didn't stop fleas after Flumethrin + Imidacloprid (Seresto) 882 reports · 39% of its reports
Didn't stop fleas after Imidacloprid 1,054 reports · 55% of its reports
Didn't stop fleas after Fipronil 394 reports · 28% of its reports
Didn't stop fleas after Lufenuron 44 reports · 4.3% of its reports
Didn't stop fleas after Imidacloprid + Permethrin + Pyriproxyfen 219 reports · 30% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with didn't stop fleas