Vomiting after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

4,725 reports to the FDA describe vomiting in dogs given Lufenuron + Milbemycin Oxime. That is 18% of all reports for this medicine, compared with 28% across reports for all dog medicines, so it is reported less often than average with this medicine.

4,725Reports

20%Marked serious

52%Recovered

2.9%Died or euthanised

Same dayTypical onset

How soon it started

Same day

1,362 57%

1–2 days

300 12%

3–7 days

90 3.7%

1–4 weeks

185 7.7%

Over a month

470 20%

How the animals did

Recovered

2,459 52%

Recovered with lasting effects

9 0.2%

Still unwell when reported

299 6.3%

Died

101 2.1%

Euthanised

38 0.8%

Not known

1,819 38%

Problems reported at the same time

1,062 22%

913 19%

725 15%

247 5.2%

Didn't work as expected

222 4.7%

Liver problems

159 3.4%

Death

136 2.9%

Tremors

126 2.7%

Age of the animals

Under 1 year

951

1–3 years

1,515

4–7 years

1,131

8–11 years

710

12+ years

275

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause vomiting in dogs?: 4,725 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

Vomiting after Spinosad (Comfortis) 30,909 reports · 54% of its reports
Vomiting after Imidacloprid + Moxidectin (Advantage Multi) 1,904 reports · 15% of its reports
Vomiting after Nitenpyram (Capstar) 1,204 reports · 11% of its reports
Vomiting after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 1,925 reports · 19% of its reports
Vomiting after Fipronil + S-methoprene (Frontline Plus) 627 reports · 21% of its reports
Vomiting after Flumethrin + Imidacloprid (Seresto) 295 reports · 13% of its reports
Vomiting after Imidacloprid 251 reports · 13% of its reports
Vomiting after Fipronil 417 reports · 30% of its reports
Vomiting after Lufenuron 325 reports · 32% of its reports
Vomiting after Imidacloprid + Permethrin + Pyriproxyfen 116 reports · 16% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with vomiting