Liver problems after Lufenuron + Milbemycin Oxime (Sentinel) in dogs
414 reports to the FDA describe liver problems in dogs given Lufenuron + Milbemycin Oxime. That is 1.6% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported less often than average with this medicine.
414Reports
49%Marked serious
9.2%Recovered
18%Died or euthanised
10 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).
Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Lufenuron + Milbemycin Oxime cause liver problems in dogs?
- 414 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 10 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Liver problems with similar medicines
- Liver problems after Spinosad (Comfortis) 955 reports · 1.7% of its reports
- Liver problems after Imidacloprid + Moxidectin (Advantage Multi) 197 reports · 1.5% of its reports
- Liver problems after Nitenpyram (Capstar) 87 reports · 0.8% of its reports
- Liver problems after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 132 reports · 1.3% of its reports
- Liver problems after Fipronil + S-methoprene (Frontline Plus) 68 reports · 2.3% of its reports
- Liver problems after Flumethrin + Imidacloprid (Seresto) 47 reports · 2.1% of its reports
- Liver problems after Fipronil 53 reports · 3.8% of its reports
- Liver problems after Lufenuron 53 reports · 5.2% of its reports
- Liver problems after Imidacloprid + Permethrin + Pyriproxyfen 21 reports · 2.8% of its reports
- Liver problems after Imidacloprid + Permethrin 24 reports · 5.1% of its reports
All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with liver problems