Liver problems after Flumethrin + Imidacloprid (Seresto) in dogs

47 reports to the FDA describe liver problems in dogs given Flumethrin + Imidacloprid. That is 2.1% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

47Reports

81%Marked serious

11%Recovered

26%Died or euthanised

18 daysTypical onset

How soon it started

Same day

4 17%

1–2 days

3 13%

3–7 days

3 13%

1–4 weeks

7 29%

Over a month

7 29%

How the animals did

Recovered

4 8.5%

Recovered with lasting effects

1 2.1%

Still unwell when reported

10 21%

Died

6 13%

Euthanised

6 13%

Not known

20 43%

Problems reported at the same time

26 55%

24 51%

21 45%

12 26%

11 23%

10 21%

10 21%

10 21%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Products with this combination include Seresto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Flumethrin + Imidacloprid cause liver problems in dogs?: 47 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 18 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

Liver problems after Spinosad (Comfortis) 955 reports · 1.7% of its reports
Liver problems after Lufenuron + Milbemycin Oxime (Sentinel) 414 reports · 1.6% of its reports
Liver problems after Imidacloprid + Moxidectin (Advantage Multi) 197 reports · 1.5% of its reports
Liver problems after Nitenpyram (Capstar) 87 reports · 0.8% of its reports
Liver problems after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 132 reports · 1.3% of its reports
Liver problems after Fipronil + S-methoprene (Frontline Plus) 68 reports · 2.3% of its reports
Liver problems after Fipronil 53 reports · 3.8% of its reports
Liver problems after Lufenuron 53 reports · 5.2% of its reports
Liver problems after Imidacloprid + Permethrin + Pyriproxyfen 21 reports · 2.8% of its reports
Liver problems after Imidacloprid + Permethrin 24 reports · 5.1% of its reports

All reported side effects of Flumethrin + Imidacloprid in dogs · Medicines most reported with liver problems