Leucocytosis after Flumethrin + Imidacloprid (Seresto) in dogs

22 reports to the FDA describe leucocytosis in dogs given Flumethrin + Imidacloprid. That is 1.0% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

22Reports
91%Marked serious
4.5%Recovered
23%Died or euthanised
4 daysTypical onset
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How soon it started

Same day
2 17%
1–2 days
4 33%
3–7 days
1 8.3%
1–4 weeks
2 17%
Over a month
3 25%

How the animals did

Recovered with lasting effects
1 4.5%
Still unwell when reported
2 9.1%
Died
4 18%
Euthanised
1 4.5%
Not known
14 64%

Problems reported at the same time

11 50%
10 45%
Monocytosis
10 45%
7 32%

Age of the animals

Under 1 year
2
1–3 years
5
4–7 years
8
8–11 years
4
12+ years
3

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Products with this combination include Seresto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Flumethrin + Imidacloprid cause leucocytosis in dogs?
22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 4 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucocytosis with similar medicines

All reported side effects of Flumethrin + Imidacloprid in dogs · Medicines most reported with leucocytosis