Leucocytosis after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

34 reports to the FDA describe leucocytosis in dogs given Lufenuron + Milbemycin Oxime + Praziquantel. That is 0.3% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported less often than average with this medicine.

34Reports

94%Marked serious

18%Recovered

15%Died or euthanised

6 daysTypical onset

How soon it started

Same day

2 7.7%

1–2 days

9 35%

3–7 days

3 12%

1–4 weeks

6 23%

Over a month

6 23%

How the animals did

Recovered

6 18%

Still unwell when reported

8 24%

Died

1 2.9%

Euthanised

4 12%

Not known

15 44%

Problems reported at the same time

16 47%

15 44%

14 41%

14 41%

11 32%

11 32%

10 29%

8 24%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause leucocytosis in dogs?: 34 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 6 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucocytosis with similar medicines

Leucocytosis after Spinosad (Comfortis) 228 reports · 0.4% of its reports
Leucocytosis after Lufenuron + Milbemycin Oxime (Sentinel) 114 reports · 0.4% of its reports
Leucocytosis after Imidacloprid + Moxidectin (Advantage Multi) 60 reports · 0.5% of its reports
Leucocytosis after Nitenpyram (Capstar) 42 reports · 0.4% of its reports
Leucocytosis after Flumethrin + Imidacloprid (Seresto) 22 reports · 1.0% of its reports
Leucocytosis after Fipronil 20 reports · 1.4% of its reports
Leucocytosis after Lufenuron 23 reports · 2.3% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with leucocytosis