Leucocytosis after Fipronil in dogs

20 reports to the FDA describe leucocytosis in dogs given Fipronil. That is 1.4% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

20Reports
85%Marked serious
15%Recovered
25%Died or euthanised
19 daysTypical onset
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How soon it started

Same day
3 20%
1–2 days
1 6.7%
3–7 days
2 13%
1–4 weeks
2 13%
Over a month
7 47%

How the animals did

Recovered
2 10%
Recovered with lasting effects
1 5.0%
Still unwell when reported
8 40%
Died
2 10%
Euthanised
3 15%
Not known
4 20%

Problems reported at the same time

12 60%
Neutrophilia
12 60%
10 50%
Hyperglycaemia
8 40%

Age of the animals

Under 1 year
2
1–3 years
5
4–7 years
4
8–11 years
5
12+ years
3

About this medicine

Fipronil kills fleas and ticks (spot-on).

Questions owners ask

Can Fipronil cause leucocytosis in dogs?
20 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 19 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucocytosis with similar medicines

All reported side effects of Fipronil in dogs · Medicines most reported with leucocytosis