Kidney problems after Fipronil in dogs

30 reports to the FDA describe kidney problems in dogs given Fipronil. That is 2.1% of all reports for this medicine, compared with 2.4% across reports for all dog medicines.

30Reports

83%Marked serious

27%Recovered

40%Died or euthanised

140 daysTypical onset

How soon it started

Same day

2 13%

1–2 days

1 6.3%

3–7 days

0 0.0%

1–4 weeks

2 13%

Over a month

11 69%

How the animals did

Recovered

4 13%

Recovered with lasting effects

4 13%

Still unwell when reported

6 20%

Died

3 10%

Euthanised

9 30%

Not known

4 13%

Problems reported at the same time

17 57%

17 57%

15 50%

13 43%

12 40%

Hyperglycaemia

11 37%

Diarrhea

10 33%

Hyperphosphataemia

9 30%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fipronil kills fleas and ticks (spot-on).

Questions owners ask

Can Fipronil cause kidney problems in dogs?: 30 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 140 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Spinosad (Comfortis) 439 reports · 0.8% of its reports
Kidney problems after Lufenuron + Milbemycin Oxime (Sentinel) 162 reports · 0.6% of its reports
Kidney problems after Imidacloprid + Moxidectin (Advantage Multi) 106 reports · 0.8% of its reports
Kidney problems after Nitenpyram (Capstar) 55 reports · 0.5% of its reports
Kidney problems after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 46 reports · 0.5% of its reports
Kidney problems after Fipronil + S-methoprene (Frontline Plus) 31 reports · 1.0% of its reports
Kidney problems after Flumethrin + Imidacloprid (Seresto) 27 reports · 1.2% of its reports
Kidney problems after Lufenuron 25 reports · 2.5% of its reports

All reported side effects of Fipronil in dogs · Medicines most reported with kidney problems