Kidney problems after Fipronil + S-methoprene (Frontline Plus) in dogs

31 reports to the FDA describe kidney problems in dogs given Fipronil + S-methoprene. That is 1.0% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

31Reports

84%Marked serious

19%Recovered

32%Died or euthanised

18 daysTypical onset

How soon it started

Same day

2 12%

1–2 days

3 18%

3–7 days

1 5.9%

1–4 weeks

4 24%

Over a month

7 41%

How the animals did

Recovered

6 19%

Still unwell when reported

3 9.7%

Died

3 9.7%

Euthanised

7 23%

Not known

12 39%

Problems reported at the same time

14 45%

11 35%

11 35%

10 32%

9 29%

7 23%

5 16%

5 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fipronil kills fleas and ticks (spot-on).

Products with this combination include Frontline Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Fipronil + S-methoprene cause kidney problems in dogs?: 31 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 18 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Spinosad (Comfortis) 439 reports · 0.8% of its reports
Kidney problems after Lufenuron + Milbemycin Oxime (Sentinel) 162 reports · 0.6% of its reports
Kidney problems after Imidacloprid + Moxidectin (Advantage Multi) 106 reports · 0.8% of its reports
Kidney problems after Nitenpyram (Capstar) 55 reports · 0.5% of its reports
Kidney problems after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 46 reports · 0.5% of its reports
Kidney problems after Flumethrin + Imidacloprid (Seresto) 27 reports · 1.2% of its reports
Kidney problems after Fipronil 30 reports · 2.1% of its reports
Kidney problems after Lufenuron 25 reports · 2.5% of its reports

All reported side effects of Fipronil + S-methoprene in dogs · Medicines most reported with kidney problems