Loss of appetite after Fipronil + S-methoprene (Frontline Plus) in dogs
230 reports to the FDA describe loss of appetite in dogs given Fipronil + S-methoprene. That is 7.8% of all reports for this medicine, compared with 8.4% across reports for all dog medicines.
230Reports
67%Marked serious
41%Recovered
9.6%Died or euthanised
18 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Fipronil kills fleas and ticks (spot-on).
Products with this combination include Frontline Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Fipronil + S-methoprene cause loss of appetite in dogs?
- 230 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 18 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Loss of appetite with similar medicines
- Loss of appetite after Spinosad (Comfortis) 3,161 reports · 5.5% of its reports
- Loss of appetite after Lufenuron + Milbemycin Oxime (Sentinel) 1,500 reports · 5.8% of its reports
- Loss of appetite after Imidacloprid + Moxidectin (Advantage Multi) 1,137 reports · 8.7% of its reports
- Loss of appetite after Nitenpyram (Capstar) 807 reports · 7.5% of its reports
- Loss of appetite after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 469 reports · 4.7% of its reports
- Loss of appetite after Flumethrin + Imidacloprid (Seresto) 172 reports · 7.6% of its reports
- Loss of appetite after Imidacloprid 147 reports · 7.7% of its reports
- Loss of appetite after Fipronil 123 reports · 8.7% of its reports
- Loss of appetite after Lufenuron 126 reports · 12% of its reports
- Loss of appetite after Imidacloprid + Permethrin + Pyriproxyfen 89 reports · 12% of its reports
All reported side effects of Fipronil + S-methoprene in dogs · Medicines most reported with loss of appetite