Death after Fipronil + S-methoprene (Frontline Plus) in dogs
The FDA has received 98 reports of death in dogs after Fipronil + S-methoprene. That is 3.3% of all reports for this medicine, compared with 5.2% across reports for all dog medicines, so it is reported less often than average with this medicine.
98Reports
100%Marked serious
0.0%Recovered
99%Died or euthanised
19 daysTypical onset
Sponsored
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Fipronil kills fleas and ticks (spot-on).
Products with this combination include Frontline Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Fipronil + S-methoprene cause death in dogs?
- 98 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 19 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Death with similar medicines
- Death after Spinosad (Comfortis) 1,441 reports · 2.5% of its reports
- Death after Lufenuron + Milbemycin Oxime (Sentinel) 545 reports · 2.1% of its reports
- Death after Imidacloprid + Moxidectin (Advantage Multi) 511 reports · 3.9% of its reports
- Death after Nitenpyram (Capstar) 349 reports · 3.2% of its reports
- Death after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 139 reports · 1.4% of its reports
- Death after Flumethrin + Imidacloprid (Seresto) 69 reports · 3.0% of its reports
- Death after Imidacloprid 48 reports · 2.5% of its reports
- Death after Fipronil 52 reports · 3.7% of its reports
- Death after Lufenuron 74 reports · 7.3% of its reports
- Death after Imidacloprid + Permethrin + Pyriproxyfen 29 reports · 3.9% of its reports
All reported side effects of Fipronil + S-methoprene in dogs · Medicines most reported with death