Death after Imidacloprid + Permethrin + Pyriproxyfen in dogs

29 reports to the FDA describe death in dogs given Imidacloprid + Permethrin + Pyriproxyfen. That is 3.9% of all reports for this medicine, compared with 5.2% across reports for all dog medicines.

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How soon it started

How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Questions owners ask

Can Imidacloprid + Permethrin + Pyriproxyfen cause death in dogs?

29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

How soon after a dose was it reported?

In half of the reports with dates, it started within 17 days of the first dose.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Death with similar medicines

• Death after Spinosad (Comfortis) 1,441 reports · 2.5% of its reports
• Death after Lufenuron + Milbemycin Oxime (Sentinel) 545 reports · 2.1% of its reports
• Death after Imidacloprid + Moxidectin (Advantage Multi) 511 reports · 3.9% of its reports
• Death after Nitenpyram (Capstar) 349 reports · 3.2% of its reports
• Death after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 139 reports · 1.4% of its reports
• Death after Fipronil + S-methoprene (Frontline Plus) 98 reports · 3.3% of its reports
• Death after Flumethrin + Imidacloprid (Seresto) 69 reports · 3.0% of its reports
• Death after Imidacloprid 48 reports · 2.5% of its reports
• Death after Fipronil 52 reports · 3.7% of its reports
• Death after Lufenuron 74 reports · 7.3% of its reports

All reported side effects of Imidacloprid + Permethrin + Pyriproxyfen in dogs · Medicines most reported with death