Breathing problems after Imidacloprid + Permethrin + Pyriproxyfen in dogs

The FDA has received 34 reports of breathing problems in dogs after Imidacloprid + Permethrin + Pyriproxyfen. That is 4.6% of all reports for this medicine, compared with 2.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

34Reports

62%Marked serious

12%Recovered

15%Died or euthanised

8 daysTypical onset

How soon it started

Same day

7 27%

1–2 days

4 15%

3–7 days

2 7.7%

1–4 weeks

8 31%

Over a month

5 19%

How the animals did

Recovered

4 12%

Still unwell when reported

16 47%

Died

2 5.9%

Euthanised

3 8.8%

Not known

9 26%

Problems reported at the same time

15 44%

12 35%

11 32%

9 26%

8 24%

Restlessness or agitation

8 24%

Application site reaction

7 21%

Death

5 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Questions owners ask

Can Imidacloprid + Permethrin + Pyriproxyfen cause breathing problems in dogs?: 34 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 8 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Breathing problems with similar medicines

Breathing problems after Spinosad (Comfortis) 748 reports · 1.3% of its reports
Breathing problems after Lufenuron + Milbemycin Oxime (Sentinel) 393 reports · 1.5% of its reports
Breathing problems after Imidacloprid + Moxidectin (Advantage Multi) 499 reports · 3.8% of its reports
Breathing problems after Nitenpyram (Capstar) 472 reports · 4.4% of its reports
Breathing problems after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 137 reports · 1.4% of its reports
Breathing problems after Fipronil + S-methoprene (Frontline Plus) 132 reports · 4.5% of its reports
Breathing problems after Flumethrin + Imidacloprid (Seresto) 73 reports · 3.2% of its reports
Breathing problems after Imidacloprid 54 reports · 2.8% of its reports
Breathing problems after Fipronil 64 reports · 4.5% of its reports
Breathing problems after Cyphenothrin + Fipronil + S-methoprene 51 reports · 7.9% of its reports

All reported side effects of Imidacloprid + Permethrin + Pyriproxyfen in dogs · Medicines most reported with breathing problems