Lethargy after Imidacloprid + Permethrin + Pyriproxyfen in dogs

106 reports to the FDA describe lethargy in dogs given Imidacloprid + Permethrin + Pyriproxyfen. That is 14% of all reports for this medicine, compared with 11% across reports for all dog medicines.

106Reports

53%Marked serious

30%Recovered

7.5%Died or euthanised

14 daysTypical onset

How soon it started

Same day

17 22%

1–2 days

11 14%

3–7 days

6 7.6%

1–4 weeks

16 20%

Over a month

29 37%

How the animals did

Recovered

32 30%

Still unwell when reported

24 23%

Died

3 2.8%

Euthanised

5 4.7%

Not known

42 40%

Problems reported at the same time

45 42%

43 41%

25 24%

21 20%

19 18%

15 14%

12 11%

11 10%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Questions owners ask

Can Imidacloprid + Permethrin + Pyriproxyfen cause lethargy in dogs?: 106 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 14 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

Lethargy after Spinosad (Comfortis) 7,303 reports · 13% of its reports
Lethargy after Lufenuron + Milbemycin Oxime (Sentinel) 2,341 reports · 9.0% of its reports
Lethargy after Imidacloprid + Moxidectin (Advantage Multi) 2,000 reports · 15% of its reports
Lethargy after Nitenpyram (Capstar) 1,204 reports · 11% of its reports
Lethargy after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 666 reports · 6.7% of its reports
Lethargy after Fipronil + S-methoprene (Frontline Plus) 447 reports · 15% of its reports
Lethargy after Flumethrin + Imidacloprid (Seresto) 250 reports · 11% of its reports
Lethargy after Imidacloprid 196 reports · 10% of its reports
Lethargy after Fipronil 185 reports · 13% of its reports
Lethargy after Lufenuron 205 reports · 20% of its reports

All reported side effects of Imidacloprid + Permethrin + Pyriproxyfen in dogs · Medicines most reported with lethargy