Lethargy after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

The FDA has received 666 reports of lethargy in dogs after Lufenuron + Milbemycin Oxime + Praziquantel. That is 6.7% of all reports for this medicine, compared with 11% across reports for all dog medicines, so it is reported less often than average with this medicine.

666Reports

51%Marked serious

49%Recovered

5.3%Died or euthanised

1 daysTypical onset

How soon it started

Same day

242 49%

1–2 days

125 25%

3–7 days

27 5.5%

1–4 weeks

42 8.5%

Over a month

58 12%

How the animals did

Recovered

321 48%

Recovered with lasting effects

6 0.9%

Still unwell when reported

157 24%

Died

12 1.8%

Euthanised

23 3.5%

Not known

147 22%

Problems reported at the same time

278 42%

259 39%

150 23%

70 11%

61 9.2%

52 7.8%

44 6.6%

42 6.3%

Age of the animals

Under 1 year

138

1–3 years

185

4–7 years

158

8–11 years

116

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause lethargy in dogs?: 666 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

Lethargy after Spinosad (Comfortis) 7,303 reports · 13% of its reports
Lethargy after Lufenuron + Milbemycin Oxime (Sentinel) 2,341 reports · 9.0% of its reports
Lethargy after Imidacloprid + Moxidectin (Advantage Multi) 2,000 reports · 15% of its reports
Lethargy after Nitenpyram (Capstar) 1,204 reports · 11% of its reports
Lethargy after Fipronil + S-methoprene (Frontline Plus) 447 reports · 15% of its reports
Lethargy after Flumethrin + Imidacloprid (Seresto) 250 reports · 11% of its reports
Lethargy after Imidacloprid 196 reports · 10% of its reports
Lethargy after Fipronil 185 reports · 13% of its reports
Lethargy after Lufenuron 205 reports · 20% of its reports
Lethargy after Imidacloprid + Permethrin + Pyriproxyfen 106 reports · 14% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with lethargy