Behaviour change after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

128 reports to the FDA describe behaviour change in dogs given Lufenuron + Milbemycin Oxime + Praziquantel. That is 1.3% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported less often than average with this medicine.

128Reports

59%Marked serious

48%Recovered

5.5%Died or euthanised

1 daysTypical onset

How soon it started

Same day

40 50%

1–2 days

17 21%

3–7 days

2 2.5%

1–4 weeks

6 7.5%

Over a month

15 19%

How the animals did

Recovered

57 45%

Recovered with lasting effects

4 3.1%

Still unwell when reported

32 25%

Died

3 2.3%

Euthanised

4 3.1%

Not known

28 22%

Problems reported at the same time

42 33%

39 30%

35 27%

20 16%

14 11%

14 11%

14 11%

11 8.6%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause behaviour change in dogs?: 128 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

Behaviour change after Spinosad (Comfortis) 1,176 reports · 2.1% of its reports
Behaviour change after Lufenuron + Milbemycin Oxime (Sentinel) 358 reports · 1.4% of its reports
Behaviour change after Imidacloprid + Moxidectin (Advantage Multi) 1,205 reports · 9.2% of its reports
Behaviour change after Nitenpyram (Capstar) 323 reports · 3.0% of its reports
Behaviour change after Fipronil + S-methoprene (Frontline Plus) 181 reports · 6.1% of its reports
Behaviour change after Flumethrin + Imidacloprid (Seresto) 167 reports · 7.3% of its reports
Behaviour change after Imidacloprid 94 reports · 4.9% of its reports
Behaviour change after Fipronil 66 reports · 4.7% of its reports
Behaviour change after Lufenuron 20 reports · 2.0% of its reports
Behaviour change after Imidacloprid + Permethrin + Pyriproxyfen 70 reports · 9.5% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with behaviour change