Restlessness or agitation after Imidacloprid + Permethrin + Pyriproxyfen in dogs

The FDA has received 56 reports of restlessness or agitation in dogs after Imidacloprid + Permethrin + Pyriproxyfen. That is 7.6% of all reports for this medicine, compared with 1.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

56Reports

39%Marked serious

30%Recovered

1.8%Died or euthanised

17 daysTypical onset

How soon it started

Same day

10 24%

1–2 days

4 9.5%

3–7 days

1 2.4%

1–4 weeks

12 29%

Over a month

15 36%

How the animals did

Recovered

17 30%

Still unwell when reported

12 21%

Euthanised

1 1.8%

Not known

26 46%

Problems reported at the same time

33 59%

18 32%

13 23%

12 21%

10 18%

10 18%

8 14%

7 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Questions owners ask

Can Imidacloprid + Permethrin + Pyriproxyfen cause restlessness or agitation in dogs?: 56 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 17 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

Restlessness or agitation after Spinosad (Comfortis) 658 reports · 1.2% of its reports
Restlessness or agitation after Lufenuron + Milbemycin Oxime (Sentinel) 255 reports · 1.0% of its reports
Restlessness or agitation after Imidacloprid + Moxidectin (Advantage Multi) 835 reports · 6.4% of its reports
Restlessness or agitation after Nitenpyram (Capstar) 596 reports · 5.5% of its reports
Restlessness or agitation after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 73 reports · 0.7% of its reports
Restlessness or agitation after Fipronil + S-methoprene (Frontline Plus) 119 reports · 4.0% of its reports
Restlessness or agitation after Flumethrin + Imidacloprid (Seresto) 68 reports · 3.0% of its reports
Restlessness or agitation after Imidacloprid 44 reports · 2.3% of its reports
Restlessness or agitation after Fipronil 40 reports · 2.8% of its reports
Restlessness or agitation after Cyphenothrin + Fipronil + S-methoprene 222 reports · 34% of its reports

All reported side effects of Imidacloprid + Permethrin + Pyriproxyfen in dogs · Medicines most reported with restlessness or agitation