Vocalising after Imidacloprid + Permethrin + Pyriproxyfen in dogs

29 reports to the FDA describe vocalising in dogs given Imidacloprid + Permethrin + Pyriproxyfen. That is 3.9% of all reports for this medicine, compared with 1.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

29Reports

45%Marked serious

34%Recovered

0.0%Died or euthanised

8 daysTypical onset

How soon it started

Same day

3 16%

1–2 days

2 11%

3–7 days

4 21%

1–4 weeks

4 21%

Over a month

6 32%

How the animals did

Recovered

10 34%

Still unwell when reported

5 17%

Not known

14 48%

Problems reported at the same time

Itching

15 52%

Behaviour change

12 41%

Restlessness or agitation

12 41%

7 24%

7 24%

6 21%

6 21%

Application site reaction

5 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Questions owners ask

Can Imidacloprid + Permethrin + Pyriproxyfen cause vocalising in dogs?: 29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 8 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Spinosad (Comfortis) 586 reports · 1.0% of its reports
Vocalising after Lufenuron + Milbemycin Oxime (Sentinel) 180 reports · 0.7% of its reports
Vocalising after Imidacloprid + Moxidectin (Advantage Multi) 295 reports · 2.2% of its reports
Vocalising after Nitenpyram (Capstar) 262 reports · 2.4% of its reports
Vocalising after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 45 reports · 0.5% of its reports
Vocalising after Fipronil + S-methoprene (Frontline Plus) 67 reports · 2.3% of its reports
Vocalising after Flumethrin + Imidacloprid (Seresto) 53 reports · 2.3% of its reports
Vocalising after Imidacloprid 46 reports · 2.4% of its reports
Vocalising after Fipronil 28 reports · 2.0% of its reports
Vocalising after Cyphenothrin + Fipronil + S-methoprene 55 reports · 8.5% of its reports

All reported side effects of Imidacloprid + Permethrin + Pyriproxyfen in dogs · Medicines most reported with vocalising