Vocalising after Spinosad (Comfortis) in dogs

586 reports to the FDA describe vocalising in dogs given Spinosad. That is 1.0% of all reports for this medicine, compared with 1.2% across reports for all dog medicines.

586Reports

25%Marked serious

37%Recovered

9.6%Died or euthanised

1 daysTypical onset

How soon it started

Same day

136 45%

1–2 days

42 14%

3–7 days

11 3.7%

1–4 weeks

20 6.7%

Over a month

91 30%

How the animals did

Recovered

155 26%

Recovered with lasting effects

64 11%

Still unwell when reported

37 6.3%

Died

44 7.5%

Euthanised

12 2.0%

Not known

274 47%

Problems reported at the same time

236 40%

139 24%

133 23%

128 22%

124 21%

Restlessness or agitation

86 15%

Seizures

69 12%

Itching

68 12%

Age of the animals

Under 1 year

1–3 years

192

4–7 years

135

8–11 years

12+ years

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause vocalising in dogs?: 586 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Lufenuron + Milbemycin Oxime (Sentinel) 180 reports · 0.7% of its reports
Vocalising after Imidacloprid + Moxidectin (Advantage Multi) 295 reports · 2.2% of its reports
Vocalising after Nitenpyram (Capstar) 262 reports · 2.4% of its reports
Vocalising after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 45 reports · 0.5% of its reports
Vocalising after Fipronil + S-methoprene (Frontline Plus) 67 reports · 2.3% of its reports
Vocalising after Flumethrin + Imidacloprid (Seresto) 53 reports · 2.3% of its reports
Vocalising after Imidacloprid 46 reports · 2.4% of its reports
Vocalising after Fipronil 28 reports · 2.0% of its reports
Vocalising after Imidacloprid + Permethrin + Pyriproxyfen 29 reports · 3.9% of its reports
Vocalising after Cyphenothrin + Fipronil + S-methoprene 55 reports · 8.5% of its reports

All reported side effects of Spinosad in dogs · Medicines most reported with vocalising