Vocalising after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

180 reports to the FDA describe vocalising in dogs given Lufenuron + Milbemycin Oxime. That is 0.7% of all reports for this medicine, compared with 1.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

180Reports
54%Marked serious
42%Recovered
11%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
32 35%
1–2 days
23 25%
3–7 days
8 8.7%
1–4 weeks
8 8.7%
Over a month
21 23%

How the animals did

Recovered
75 42%
Recovered with lasting effects
1 0.6%
Still unwell when reported
20 11%
Died
9 5.0%
Euthanised
10 5.6%
Not known
65 36%

Problems reported at the same time

Age of the animals

Under 1 year
42
1–3 years
46
4–7 years
45
8–11 years
30
12+ years
17

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause vocalising in dogs?
180 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with vocalising