Vocalising after Cyphenothrin + Fipronil + S-methoprene in dogs

55 reports to the FDA describe vocalising in dogs given Cyphenothrin + Fipronil + S-methoprene. That is 8.5% of all reports for this medicine, compared with 1.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

55Reports

85%Marked serious

45%Recovered

1.8%Died or euthanised

31 daysTypical onset

How soon it started

Same day

8 24%

1–2 days

3 9.1%

3–7 days

1 3.0%

1–4 weeks

4 12%

Over a month

17 52%

How the animals did

Recovered

25 45%

Still unwell when reported

3 5.5%

Died

1 1.8%

Not known

26 47%

Problems reported at the same time

Restlessness or agitation

34 62%

Itching

31 56%

Breathing problems

13 24%

Tremors

11 20%

Application site reaction

9 16%

Behaviour change

9 16%

Not sleeping

4 7.3%

Barking

3 5.5%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fipronil kills fleas and ticks (spot-on).

Questions owners ask

Can Cyphenothrin + Fipronil + S-methoprene cause vocalising in dogs?: 55 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 31 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Spinosad (Comfortis) 586 reports · 1.0% of its reports
Vocalising after Lufenuron + Milbemycin Oxime (Sentinel) 180 reports · 0.7% of its reports
Vocalising after Imidacloprid + Moxidectin (Advantage Multi) 295 reports · 2.2% of its reports
Vocalising after Nitenpyram (Capstar) 262 reports · 2.4% of its reports
Vocalising after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 45 reports · 0.5% of its reports
Vocalising after Fipronil + S-methoprene (Frontline Plus) 67 reports · 2.3% of its reports
Vocalising after Flumethrin + Imidacloprid (Seresto) 53 reports · 2.3% of its reports
Vocalising after Imidacloprid 46 reports · 2.4% of its reports
Vocalising after Fipronil 28 reports · 2.0% of its reports
Vocalising after Imidacloprid + Permethrin + Pyriproxyfen 29 reports · 3.9% of its reports

All reported side effects of Cyphenothrin + Fipronil + S-methoprene in dogs · Medicines most reported with vocalising