Application site reaction after Cyphenothrin + Fipronil + S-methoprene in dogs

83 reports to the FDA describe application site reaction in dogs given Cyphenothrin + Fipronil + S-methoprene. That is 13% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

83Reports

93%Marked serious

30%Recovered

0.0%Died or euthanised

1 daysTypical onset

How soon it started

Same day

24 45%

1–2 days

8 15%

3–7 days

5 9.4%

1–4 weeks

1 1.9%

Over a month

15 28%

How the animals did

Recovered

25 30%

Still unwell when reported

5 6.0%

Not known

53 64%

Problems reported at the same time

Itching

48 58%

Restlessness or agitation

35 42%

10 12%

9 11%

7 8.4%

7 8.4%

Skin rash or irritation

6 7.2%

Breathing problems

6 7.2%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fipronil kills fleas and ticks (spot-on).

Questions owners ask

Can Cyphenothrin + Fipronil + S-methoprene cause application site reaction in dogs?: 83 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Application site reaction with similar medicines

Application site reaction after Imidacloprid + Moxidectin (Advantage Multi) 658 reports · 5.0% of its reports
Application site reaction after Fipronil + S-methoprene (Frontline Plus) 185 reports · 6.3% of its reports
Application site reaction after Flumethrin + Imidacloprid (Seresto) 123 reports · 5.4% of its reports
Application site reaction after Imidacloprid + Permethrin + Pyriproxyfen 40 reports · 5.4% of its reports
Application site reaction after Amitraz + Fipronil + S-methoprene 73 reports · 16% of its reports
Application site reaction after Fipronil + Pyriproxyfen + S-methoprene 24 reports · 5.6% of its reports

All reported side effects of Cyphenothrin + Fipronil + S-methoprene in dogs · Medicines most reported with application site reaction