Application site reaction after Fipronil + Pyriproxyfen + S-methoprene in dogs

The FDA has received 24 reports of application site reaction in dogs after Fipronil + Pyriproxyfen + S-methoprene. That is 5.6% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

24Reports

33%Marked serious

25%Recovered

0.0%Died or euthanised

18 daysTypical onset

How soon it started

Same day

2 14%

1–2 days

3 21%

3–7 days

0 0.0%

1–4 weeks

5 36%

Over a month

4 29%

How the animals did

Recovered

6 25%

Still unwell when reported

3 13%

Not known

15 63%

Problems reported at the same time

Itching

6 25%

Lethargy

4 17%

Hair loss

2 8.3%

Anxiety

2 8.3%

Increased skin sensitivity

1 4.2%

Appetite loss

1 4.2%

Mucus in eye

1 4.2%

Reddening of the skin

1 4.2%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fipronil kills fleas and ticks (spot-on).

Questions owners ask

Can Fipronil + Pyriproxyfen + S-methoprene cause application site reaction in dogs?: 24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 18 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Application site reaction with similar medicines

Application site reaction after Imidacloprid + Moxidectin (Advantage Multi) 658 reports · 5.0% of its reports
Application site reaction after Fipronil + S-methoprene (Frontline Plus) 185 reports · 6.3% of its reports
Application site reaction after Flumethrin + Imidacloprid (Seresto) 123 reports · 5.4% of its reports
Application site reaction after Imidacloprid + Permethrin + Pyriproxyfen 40 reports · 5.4% of its reports
Application site reaction after Cyphenothrin + Fipronil + S-methoprene 83 reports · 13% of its reports
Application site reaction after Amitraz + Fipronil + S-methoprene 73 reports · 16% of its reports

All reported side effects of Fipronil + Pyriproxyfen + S-methoprene in dogs · Medicines most reported with application site reaction