Fipronil + Pyriproxyfen + S-methoprene side effects in dogs
431 reports sent to the FDA between 2016 and 2026 involve Fipronil + Pyriproxyfen + S-methoprene in dogs. The most reported problems were vomiting, lethargy, itching. 34% were marked serious.
431Reports
34%Marked serious
0.0%Only medicine involved
34%Recovered
3.5%Died or euthanised
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About this medicine
Fipronil kills fleas and ticks (spot-on).
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (267 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Labrador Retriever 26 reports
- Golden Retriever 23 reports
- German Shepherd Dog 22 reports
- Chihuahua 13 reports
- Shih Tzu 10 reports
- Beagle 9 reports
- Border Collie 9 reports
- Maltese 8 reports
- Australian Shepherd Dog 8 reports
- Jack Russell Terrier 7 reports
Other flea and tick treatments for dogs
Spinosad (Comfortis)57,095 reports · 7.7% seriousLufenuron + Milbemycin Oxime (Sentinel)26,051 reports · 24% seriousImidacloprid + Moxidectin (Advantage Multi)13,117 reports · 57% seriousNitenpyram (Capstar)10,782 reports · 10.0% seriousLufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum)9,966 reports · 40% seriousFipronil + S-methoprene (Frontline Plus)2,954 reports · 49% seriousFlumethrin + Imidacloprid (Seresto)2,273 reports · 25% seriousImidacloprid1,908 reports · 11% serious