Didn't stop ticks after Fipronil + Pyriproxyfen + S-methoprene in dogs

33 reports to the FDA describe didn't stop ticks in dogs given Fipronil + Pyriproxyfen + S-methoprene. That is 7.7% of all reports for this medicine, compared with 2.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

33Reports

3.0%Marked serious

3.0%Recovered

3.0%Died or euthanised

236 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

0 0.0%

3–7 days

0 0.0%

1–4 weeks

0 0.0%

Over a month

18 100%

How the animals did

Recovered

1 3.0%

Still unwell when reported

4 12%

Euthanised

1 3.0%

Not known

27 82%

Problems reported at the same time

Didn't work as expected

28 85%

Systemic disorder

1 3.0%

Drug dose administration interval too long

1 3.0%

Didn't stop fleas

1 3.0%

Drug dose omission

1 3.0%

Lameness

1 3.0%

Overdose

1 3.0%

Death

1 3.0%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fipronil kills fleas and ticks (spot-on).

Questions owners ask

Can Fipronil + Pyriproxyfen + S-methoprene cause didn't stop ticks in dogs?: 33 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 236 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't stop ticks with similar medicines

Didn't stop ticks after Spinosad (Comfortis) 95 reports · 0.2% of its reports
Didn't stop ticks after Lufenuron + Milbemycin Oxime (Sentinel) 42 reports · 0.2% of its reports
Didn't stop ticks after Imidacloprid + Moxidectin (Advantage Multi) 52 reports · 0.4% of its reports
Didn't stop ticks after Nitenpyram (Capstar) 51 reports · 0.5% of its reports
Didn't stop ticks after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 36 reports · 0.4% of its reports
Didn't stop ticks after Fipronil + S-methoprene (Frontline Plus) 117 reports · 4.0% of its reports
Didn't stop ticks after Flumethrin + Imidacloprid (Seresto) 158 reports · 7.0% of its reports
Didn't stop ticks after Imidacloprid + Permethrin + Pyriproxyfen 21 reports · 2.8% of its reports

All reported side effects of Fipronil + Pyriproxyfen + S-methoprene in dogs · Medicines most reported with didn't stop ticks