Didn't stop ticks after Imidacloprid + Permethrin + Pyriproxyfen in dogs

The FDA has received 21 reports of didn't stop ticks in dogs after Imidacloprid + Permethrin + Pyriproxyfen. That is 2.8% of all reports for this medicine, compared with 2.3% across reports for all dog medicines.

21Reports
19%Marked serious
0.0%Recovered
0.0%Died or euthanised
26 daysTypical onset
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How soon it started

Same day
1 9.1%
1–2 days
1 9.1%
3–7 days
1 9.1%
1–4 weeks
3 27%
Over a month
5 45%

How the animals did

Still unwell when reported
9 43%
Not known
12 57%

Problems reported at the same time

Didn't work as expected
6 29%
Itching
3 14%
Application site reaction
3 14%
Vomiting
3 14%
Diarrhea
3 14%
Breathing problems
2 9.5%
Behaviour change
2 9.5%
Skin scab
2 9.5%

Age of the animals

Under 1 year
2
1–3 years
7
4–7 years
5
8–11 years
3
12+ years
3

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Questions owners ask

Can Imidacloprid + Permethrin + Pyriproxyfen cause didn't stop ticks in dogs?
21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 26 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't stop ticks with similar medicines

All reported side effects of Imidacloprid + Permethrin + Pyriproxyfen in dogs · Medicines most reported with didn't stop ticks