Didn't stop ticks after Imidacloprid + Moxidectin (Advantage Multi) in dogs

52 reports to the FDA describe didn't stop ticks in dogs given Imidacloprid + Moxidectin. That is 0.4% of all reports for this medicine, compared with 2.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

52Reports

27%Marked serious

9.6%Recovered

3.8%Died or euthanised

20 daysTypical onset

How soon it started

Same day

3 8.1%

1–2 days

4 11%

3–7 days

4 11%

1–4 weeks

13 35%

Over a month

13 35%

How the animals did

Recovered

5 9.6%

Still unwell when reported

8 15%

Died

1 1.9%

Euthanised

1 1.9%

Not known

37 71%

Problems reported at the same time

Didn't work as expected

12 23%

7 13%

7 13%

4 7.7%

4 7.7%

3 5.8%

3 5.8%

Skin rash or irritation

3 5.8%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause didn't stop ticks in dogs?: 52 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 20 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't stop ticks with similar medicines

Didn't stop ticks after Spinosad (Comfortis) 95 reports · 0.2% of its reports
Didn't stop ticks after Lufenuron + Milbemycin Oxime (Sentinel) 42 reports · 0.2% of its reports
Didn't stop ticks after Nitenpyram (Capstar) 51 reports · 0.5% of its reports
Didn't stop ticks after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 36 reports · 0.4% of its reports
Didn't stop ticks after Fipronil + S-methoprene (Frontline Plus) 117 reports · 4.0% of its reports
Didn't stop ticks after Flumethrin + Imidacloprid (Seresto) 158 reports · 7.0% of its reports
Didn't stop ticks after Imidacloprid + Permethrin + Pyriproxyfen 21 reports · 2.8% of its reports
Didn't stop ticks after Fipronil + Pyriproxyfen + S-methoprene 33 reports · 7.7% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with didn't stop ticks