Didn't stop ticks after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

42 reports to the FDA describe didn't stop ticks in dogs given Lufenuron + Milbemycin Oxime. That is 0.2% of all reports for this medicine, compared with 2.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

42Reports

26%Marked serious

4.8%Recovered

0.0%Died or euthanised

29 daysTypical onset

How soon it started

Same day

1 8.3%

1–2 days

0 0.0%

3–7 days

3 25%

1–4 weeks

3 25%

Over a month

5 42%

How the animals did

Recovered

2 4.8%

Still unwell when reported

21 50%

Not known

19 45%

Problems reported at the same time

Didn't work as expected

19 45%

Didn't stop fleas

5 12%

Lethargy

4 9.5%

Didn't prevent heartworm

3 7.1%

Didn't stop worms

2 4.8%

Leucocytosis

2 4.8%

Arthritis

2 4.8%

Elevated globulins

1 2.4%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause didn't stop ticks in dogs?: 42 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 29 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't stop ticks with similar medicines

Didn't stop ticks after Spinosad (Comfortis) 95 reports · 0.2% of its reports
Didn't stop ticks after Imidacloprid + Moxidectin (Advantage Multi) 52 reports · 0.4% of its reports
Didn't stop ticks after Nitenpyram (Capstar) 51 reports · 0.5% of its reports
Didn't stop ticks after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 36 reports · 0.4% of its reports
Didn't stop ticks after Fipronil + S-methoprene (Frontline Plus) 117 reports · 4.0% of its reports
Didn't stop ticks after Flumethrin + Imidacloprid (Seresto) 158 reports · 7.0% of its reports
Didn't stop ticks after Imidacloprid + Permethrin + Pyriproxyfen 21 reports · 2.8% of its reports
Didn't stop ticks after Fipronil + Pyriproxyfen + S-methoprene 33 reports · 7.7% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with didn't stop ticks