Skin rash or irritation after Imidacloprid + Moxidectin (Advantage Multi) in dogs

504 reports to the FDA describe skin rash or irritation in dogs given Imidacloprid + Moxidectin. That is 3.8% of all reports for this medicine, compared with 1.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

504Reports

68%Marked serious

30%Recovered

3.6%Died or euthanised

7 daysTypical onset

How soon it started

Same day

48 15%

1–2 days

59 19%

3–7 days

59 19%

1–4 weeks

102 32%

Over a month

48 15%

How the animals did

Recovered

148 29%

Recovered with lasting effects

3 0.6%

Still unwell when reported

21 4.2%

Died

7 1.4%

Euthanised

11 2.2%

Not known

314 62%

Problems reported at the same time

Itching

243 48%

Application site reaction

97 19%

91 18%

89 18%

81 16%

53 11%

41 8.1%

39 7.7%

Age of the animals

Under 1 year

1–3 years

145

4–7 years

144

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause skin rash or irritation in dogs?: 504 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 7 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin rash or irritation with similar medicines

Skin rash or irritation after Spinosad (Comfortis) 726 reports · 1.3% of its reports
Skin rash or irritation after Lufenuron + Milbemycin Oxime (Sentinel) 344 reports · 1.3% of its reports
Skin rash or irritation after Nitenpyram (Capstar) 163 reports · 1.5% of its reports
Skin rash or irritation after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 45 reports · 0.5% of its reports
Skin rash or irritation after Fipronil + S-methoprene (Frontline Plus) 62 reports · 2.1% of its reports
Skin rash or irritation after Flumethrin + Imidacloprid (Seresto) 103 reports · 4.5% of its reports
Skin rash or irritation after Imidacloprid 44 reports · 2.3% of its reports
Skin rash or irritation after Fipronil 30 reports · 2.1% of its reports
Skin rash or irritation after Lufenuron 60 reports · 5.9% of its reports
Skin rash or irritation after Imidacloprid + Permethrin + Pyriproxyfen 25 reports · 3.4% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with skin rash or irritation