Skin rash or irritation after Spinosad (Comfortis) in dogs

726 reports to the FDA describe skin rash or irritation in dogs given Spinosad. That is 1.3% of all reports for this medicine, compared with 1.3% across reports for all dog medicines.

726Reports

14%Marked serious

28%Recovered

2.8%Died or euthanised

15 daysTypical onset

How soon it started

Same day

68 26%

1–2 days

32 12%

3–7 days

20 7.6%

1–4 weeks

36 14%

Over a month

107 41%

How the animals did

Recovered

93 13%

Recovered with lasting effects

112 15%

Still unwell when reported

62 8.5%

Died

13 1.8%

Euthanised

7 1.0%

Not known

439 60%

Problems reported at the same time

264 36%

145 20%

109 15%

97 13%

78 11%

59 8.1%

57 7.9%

41 5.6%

Age of the animals

Under 1 year

1–3 years

218

4–7 years

220

8–11 years

143

12+ years

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause skin rash or irritation in dogs?: 726 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 15 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin rash or irritation with similar medicines

Skin rash or irritation after Lufenuron + Milbemycin Oxime (Sentinel) 344 reports · 1.3% of its reports
Skin rash or irritation after Imidacloprid + Moxidectin (Advantage Multi) 504 reports · 3.8% of its reports
Skin rash or irritation after Nitenpyram (Capstar) 163 reports · 1.5% of its reports
Skin rash or irritation after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 45 reports · 0.5% of its reports
Skin rash or irritation after Fipronil + S-methoprene (Frontline Plus) 62 reports · 2.1% of its reports
Skin rash or irritation after Flumethrin + Imidacloprid (Seresto) 103 reports · 4.5% of its reports
Skin rash or irritation after Imidacloprid 44 reports · 2.3% of its reports
Skin rash or irritation after Fipronil 30 reports · 2.1% of its reports
Skin rash or irritation after Lufenuron 60 reports · 5.9% of its reports
Skin rash or irritation after Imidacloprid + Permethrin + Pyriproxyfen 25 reports · 3.4% of its reports

All reported side effects of Spinosad in dogs · Medicines most reported with skin rash or irritation