Skin rash or irritation after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

The FDA has received 344 reports of skin rash or irritation in dogs after Lufenuron + Milbemycin Oxime. That is 1.3% of all reports for this medicine, compared with 1.3% across reports for all dog medicines.

344Reports

27%Marked serious

17%Recovered

2.6%Died or euthanised

3 daysTypical onset

How soon it started

Same day

22 22%

1–2 days

23 23%

3–7 days

10 10%

1–4 weeks

19 19%

Over a month

26 26%

How the animals did

Recovered

55 16%

Recovered with lasting effects

3 0.9%

Still unwell when reported

50 15%

Died

7 2.0%

Euthanised

2 0.6%

Not known

227 66%

Problems reported at the same time

164 48%

50 15%

41 12%

35 10%

32 9.3%

26 7.6%

25 7.3%

23 6.7%

Age of the animals

Under 1 year

1–3 years

4–7 years

123

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause skin rash or irritation in dogs?: 344 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin rash or irritation with similar medicines

Skin rash or irritation after Spinosad (Comfortis) 726 reports · 1.3% of its reports
Skin rash or irritation after Imidacloprid + Moxidectin (Advantage Multi) 504 reports · 3.8% of its reports
Skin rash or irritation after Nitenpyram (Capstar) 163 reports · 1.5% of its reports
Skin rash or irritation after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 45 reports · 0.5% of its reports
Skin rash or irritation after Fipronil + S-methoprene (Frontline Plus) 62 reports · 2.1% of its reports
Skin rash or irritation after Flumethrin + Imidacloprid (Seresto) 103 reports · 4.5% of its reports
Skin rash or irritation after Imidacloprid 44 reports · 2.3% of its reports
Skin rash or irritation after Fipronil 30 reports · 2.1% of its reports
Skin rash or irritation after Lufenuron 60 reports · 5.9% of its reports
Skin rash or irritation after Imidacloprid + Permethrin + Pyriproxyfen 25 reports · 3.4% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with skin rash or irritation