Hair loss after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

The FDA has received 227 reports of hair loss in dogs after Lufenuron + Milbemycin Oxime. That is 0.9% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

227Reports
31%Marked serious
13%Recovered
2.6%Died or euthanised
10 daysTypical onset
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How soon it started

Same day
21 22%
1–2 days
15 16%
3–7 days
9 9.6%
1–4 weeks
19 20%
Over a month
30 32%

How the animals did

Recovered
27 12%
Recovered with lasting effects
2 0.9%
Still unwell when reported
58 26%
Died
4 1.8%
Euthanised
2 0.9%
Not known
134 59%

Problems reported at the same time

Age of the animals

Under 1 year
34
1–3 years
67
4–7 years
62
8–11 years
40
12+ years
12

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause hair loss in dogs?
227 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 10 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hair loss with similar medicines

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with hair loss