Diarrhea after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

2,524 reports to the FDA describe diarrhea in dogs given Lufenuron + Milbemycin Oxime. That is 9.7% of all reports for this medicine, compared with 8.4% across reports for all dog medicines.

2,524Reports

29%Marked serious

29%Recovered

3.5%Died or euthanised

2 daysTypical onset

How soon it started

Same day

311 29%

1–2 days

224 21%

3–7 days

97 9.2%

1–4 weeks

223 21%

Over a month

200 19%

How the animals did

Recovered

726 29%

Recovered with lasting effects

4 0.2%

Still unwell when reported

258 10%

Died

52 2.1%

Euthanised

37 1.5%

Not known

1,447 57%

Problems reported at the same time

1,062 42%

558 22%

520 21%

478 19%

Didn't work as expected

432 17%

Weight loss

92 3.6%

Death

87 3.4%

Dehydration

74 2.9%

Age of the animals

Under 1 year

526

1–3 years

746

4–7 years

577

8–11 years

408

12+ years

220

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause diarrhea in dogs?: 2,524 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diarrhea with similar medicines

Diarrhea after Spinosad (Comfortis) 2,388 reports · 4.2% of its reports
Diarrhea after Imidacloprid + Moxidectin (Advantage Multi) 1,203 reports · 9.2% of its reports
Diarrhea after Nitenpyram (Capstar) 626 reports · 5.8% of its reports
Diarrhea after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 800 reports · 8.0% of its reports
Diarrhea after Fipronil + S-methoprene (Frontline Plus) 230 reports · 7.8% of its reports
Diarrhea after Flumethrin + Imidacloprid (Seresto) 130 reports · 5.7% of its reports
Diarrhea after Imidacloprid 93 reports · 4.9% of its reports
Diarrhea after Fipronil 123 reports · 8.7% of its reports
Diarrhea after Lufenuron 182 reports · 18% of its reports
Diarrhea after Imidacloprid + Permethrin + Pyriproxyfen 53 reports · 7.2% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with diarrhea