Weight loss after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

The FDA has received 280 reports of weight loss in dogs after Lufenuron + Milbemycin Oxime. That is 1.1% of all reports for this medicine, compared with 1.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

280Reports

55%Marked serious

17%Recovered

18%Died or euthanised

12 daysTypical onset

How soon it started

Same day

21 19%

1–2 days

13 12%

3–7 days

10 9.2%

1–4 weeks

29 27%

Over a month

36 33%

How the animals did

Recovered

43 15%

Recovered with lasting effects

5 1.8%

Still unwell when reported

51 18%

Died

28 10%

Euthanised

22 7.9%

Not known

131 47%

Problems reported at the same time

128 46%

106 38%

93 33%

92 33%

51 18%

50 18%

46 16%

Didn't work as expected

43 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause weight loss in dogs?: 280 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 12 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weight loss with similar medicines

Weight loss after Spinosad (Comfortis) 531 reports · 0.9% of its reports
Weight loss after Imidacloprid + Moxidectin (Advantage Multi) 236 reports · 1.8% of its reports
Weight loss after Nitenpyram (Capstar) 89 reports · 0.8% of its reports
Weight loss after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 77 reports · 0.8% of its reports
Weight loss after Fipronil + S-methoprene (Frontline Plus) 29 reports · 1.0% of its reports
Weight loss after Flumethrin + Imidacloprid (Seresto) 57 reports · 2.5% of its reports
Weight loss after Fipronil 28 reports · 2.0% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with weight loss