Weight loss after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

77 reports to the FDA describe weight loss in dogs given Lufenuron + Milbemycin Oxime + Praziquantel. That is 0.8% of all reports for this medicine, compared with 1.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

77Reports

86%Marked serious

17%Recovered

17%Died or euthanised

11 daysTypical onset

How soon it started

Same day

8 22%

1–2 days

4 11%

3–7 days

4 11%

1–4 weeks

11 30%

Over a month

10 27%

How the animals did

Recovered

11 14%

Recovered with lasting effects

2 2.6%

Still unwell when reported

31 40%

Died

5 6.5%

Euthanised

8 10%

Not known

20 26%

Problems reported at the same time

30 39%

25 32%

22 29%

20 26%

15 19%

Didn't work as expected

15 19%

Death

14 18%

Didn't stop worms

10 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause weight loss in dogs?: 77 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 11 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weight loss with similar medicines

Weight loss after Spinosad (Comfortis) 531 reports · 0.9% of its reports
Weight loss after Lufenuron + Milbemycin Oxime (Sentinel) 280 reports · 1.1% of its reports
Weight loss after Imidacloprid + Moxidectin (Advantage Multi) 236 reports · 1.8% of its reports
Weight loss after Nitenpyram (Capstar) 89 reports · 0.8% of its reports
Weight loss after Fipronil + S-methoprene (Frontline Plus) 29 reports · 1.0% of its reports
Weight loss after Flumethrin + Imidacloprid (Seresto) 57 reports · 2.5% of its reports
Weight loss after Fipronil 28 reports · 2.0% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with weight loss