Allergic reaction after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

The FDA has received 337 reports of allergic reaction in dogs after Lufenuron + Milbemycin Oxime. That is 1.3% of all reports for this medicine, compared with 2.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

337Reports

47%Marked serious

42%Recovered

2.4%Died or euthanised

1 daysTypical onset

How soon it started

Same day

78 45%

1–2 days

37 21%

3–7 days

8 4.6%

1–4 weeks

18 10%

Over a month

33 19%

How the animals did

Recovered

139 41%

Recovered with lasting effects

2 0.6%

Still unwell when reported

47 14%

Died

8 2.4%

Not known

141 42%

Problems reported at the same time

136 40%

90 27%

84 25%

79 23%

44 13%

36 11%

35 10%

Skin rash or irritation

32 9.5%

Age of the animals

Under 1 year

1–3 years

120

4–7 years

102

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause allergic reaction in dogs?: 337 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Allergic reaction with similar medicines

Allergic reaction after Spinosad (Comfortis) 534 reports · 0.9% of its reports
Allergic reaction after Imidacloprid + Moxidectin (Advantage Multi) 267 reports · 2.0% of its reports
Allergic reaction after Nitenpyram (Capstar) 189 reports · 1.8% of its reports
Allergic reaction after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 108 reports · 1.1% of its reports
Allergic reaction after Fipronil + S-methoprene (Frontline Plus) 45 reports · 1.5% of its reports
Allergic reaction after Flumethrin + Imidacloprid (Seresto) 31 reports · 1.4% of its reports
Allergic reaction after Imidacloprid 28 reports · 1.5% of its reports
Allergic reaction after Fipronil 22 reports · 1.6% of its reports
Allergic reaction after Lufenuron 73 reports · 7.2% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with allergic reaction