Allergic reaction after Fipronil + S-methoprene (Frontline Plus) in dogs
45 reports to the FDA describe allergic reaction in dogs given Fipronil + S-methoprene. That is 1.5% of all reports for this medicine, compared with 2.3% across reports for all dog medicines, so it is reported less often than average with this medicine.
45Reports
60%Marked serious
36%Recovered
0.0%Died or euthanised
31 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Fipronil kills fleas and ticks (spot-on).
Products with this combination include Frontline Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Fipronil + S-methoprene cause allergic reaction in dogs?
- 45 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 31 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Allergic reaction with similar medicines
- Allergic reaction after Spinosad (Comfortis) 534 reports · 0.9% of its reports
- Allergic reaction after Lufenuron + Milbemycin Oxime (Sentinel) 337 reports · 1.3% of its reports
- Allergic reaction after Imidacloprid + Moxidectin (Advantage Multi) 267 reports · 2.0% of its reports
- Allergic reaction after Nitenpyram (Capstar) 189 reports · 1.8% of its reports
- Allergic reaction after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 108 reports · 1.1% of its reports
- Allergic reaction after Flumethrin + Imidacloprid (Seresto) 31 reports · 1.4% of its reports
- Allergic reaction after Imidacloprid 28 reports · 1.5% of its reports
- Allergic reaction after Fipronil 22 reports · 1.6% of its reports
- Allergic reaction after Lufenuron 73 reports · 7.2% of its reports
All reported side effects of Fipronil + S-methoprene in dogs · Medicines most reported with allergic reaction