Allergic reaction after Imidacloprid + Moxidectin (Advantage Multi) in dogs

The FDA has received 267 reports of allergic reaction in dogs after Imidacloprid + Moxidectin. That is 2.0% of all reports for this medicine, compared with 2.3% across reports for all dog medicines.

267Reports

59%Marked serious

31%Recovered

0.7%Died or euthanised

1 daysTypical onset

How soon it started

Same day

69 47%

1–2 days

45 31%

3–7 days

15 10%

1–4 weeks

10 6.8%

Over a month

7 4.8%

How the animals did

Recovered

83 31%

Recovered with lasting effects

1 0.4%

Still unwell when reported

9 3.4%

Died

1 0.4%

Euthanised

1 0.4%

Not known

172 64%

Problems reported at the same time

Itching

97 36%

Swelling

77 29%

Vomiting

44 16%

Skin rash or irritation

41 15%

Skin redness

39 15%

Lethargy

29 11%

Diarrhea

22 8.2%

Application site reaction

22 8.2%

Age of the animals

Under 1 year

1–3 years

106

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause allergic reaction in dogs?: 267 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Allergic reaction with similar medicines

Allergic reaction after Spinosad (Comfortis) 534 reports · 0.9% of its reports
Allergic reaction after Lufenuron + Milbemycin Oxime (Sentinel) 337 reports · 1.3% of its reports
Allergic reaction after Nitenpyram (Capstar) 189 reports · 1.8% of its reports
Allergic reaction after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 108 reports · 1.1% of its reports
Allergic reaction after Fipronil + S-methoprene (Frontline Plus) 45 reports · 1.5% of its reports
Allergic reaction after Flumethrin + Imidacloprid (Seresto) 31 reports · 1.4% of its reports
Allergic reaction after Imidacloprid 28 reports · 1.5% of its reports
Allergic reaction after Fipronil 22 reports · 1.6% of its reports
Allergic reaction after Lufenuron 73 reports · 7.2% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with allergic reaction