Breathing problems after Fipronil + S-methoprene (Frontline Plus) in dogs
The FDA has received 132 reports of breathing problems in dogs after Fipronil + S-methoprene. That is 4.5% of all reports for this medicine, compared with 2.7% across reports for all dog medicines, so it is reported unusually often with this medicine.
132Reports
66%Marked serious
45%Recovered
11%Died or euthanised
22 daysTypical onset
Sponsored
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Fipronil kills fleas and ticks (spot-on).
Products with this combination include Frontline Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Fipronil + S-methoprene cause breathing problems in dogs?
- 132 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 22 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Breathing problems with similar medicines
- Breathing problems after Spinosad (Comfortis) 748 reports · 1.3% of its reports
- Breathing problems after Lufenuron + Milbemycin Oxime (Sentinel) 393 reports · 1.5% of its reports
- Breathing problems after Imidacloprid + Moxidectin (Advantage Multi) 499 reports · 3.8% of its reports
- Breathing problems after Nitenpyram (Capstar) 472 reports · 4.4% of its reports
- Breathing problems after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 137 reports · 1.4% of its reports
- Breathing problems after Flumethrin + Imidacloprid (Seresto) 73 reports · 3.2% of its reports
- Breathing problems after Imidacloprid 54 reports · 2.8% of its reports
- Breathing problems after Fipronil 64 reports · 4.5% of its reports
- Breathing problems after Imidacloprid + Permethrin + Pyriproxyfen 34 reports · 4.6% of its reports
- Breathing problems after Cyphenothrin + Fipronil + S-methoprene 51 reports · 7.9% of its reports
All reported side effects of Fipronil + S-methoprene in dogs · Medicines most reported with breathing problems