Swelling after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

219 reports to the FDA describe swelling in dogs given Lufenuron + Milbemycin Oxime. That is 0.8% of all reports for this medicine, compared with 2.8% across reports for all dog medicines, so it is reported less often than average with this medicine.

219Reports

50%Marked serious

31%Recovered

12%Died or euthanised

2 daysTypical onset

How soon it started

Same day

35 37%

1–2 days

17 18%

3–7 days

5 5.3%

1–4 weeks

8 8.5%

Over a month

29 31%

How the animals did

Recovered

66 30%

Recovered with lasting effects

1 0.5%

Still unwell when reported

31 14%

Died

19 8.7%

Euthanised

8 3.7%

Not known

94 43%

Problems reported at the same time

84 38%

58 26%

50 23%

42 19%

39 18%

28 13%

27 12%

24 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause swelling in dogs?: 219 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Swelling with similar medicines

Swelling after Spinosad (Comfortis) 399 reports · 0.7% of its reports
Swelling after Imidacloprid + Moxidectin (Advantage Multi) 218 reports · 1.7% of its reports
Swelling after Nitenpyram (Capstar) 127 reports · 1.2% of its reports
Swelling after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 70 reports · 0.7% of its reports
Swelling after Fipronil + S-methoprene (Frontline Plus) 42 reports · 1.4% of its reports
Swelling after Flumethrin + Imidacloprid (Seresto) 47 reports · 2.1% of its reports
Swelling after Fipronil 20 reports · 1.4% of its reports
Swelling after Lufenuron 44 reports · 4.3% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with swelling