Swelling after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

70 reports to the FDA describe swelling in dogs given Lufenuron + Milbemycin Oxime + Praziquantel. That is 0.7% of all reports for this medicine, compared with 2.8% across reports for all dog medicines, so it is reported less often than average with this medicine.

70Reports

91%Marked serious

33%Recovered

7.1%Died or euthanised

1 daysTypical onset

How soon it started

Same day

21 45%

1–2 days

5 11%

3–7 days

2 4.3%

1–4 weeks

6 13%

Over a month

13 28%

How the animals did

Recovered

22 31%

Recovered with lasting effects

1 1.4%

Still unwell when reported

35 50%

Died

3 4.3%

Euthanised

2 2.9%

Not known

7 10%

Problems reported at the same time

28 40%

22 31%

19 27%

18 26%

16 23%

10 14%

8 11%

7 10%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause swelling in dogs?: 70 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Swelling with similar medicines

Swelling after Spinosad (Comfortis) 399 reports · 0.7% of its reports
Swelling after Lufenuron + Milbemycin Oxime (Sentinel) 219 reports · 0.8% of its reports
Swelling after Imidacloprid + Moxidectin (Advantage Multi) 218 reports · 1.7% of its reports
Swelling after Nitenpyram (Capstar) 127 reports · 1.2% of its reports
Swelling after Fipronil + S-methoprene (Frontline Plus) 42 reports · 1.4% of its reports
Swelling after Flumethrin + Imidacloprid (Seresto) 47 reports · 2.1% of its reports
Swelling after Fipronil 20 reports · 1.4% of its reports
Swelling after Lufenuron 44 reports · 4.3% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with swelling