Blood problems after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

49 reports to the FDA describe blood problems in dogs given Lufenuron + Milbemycin Oxime + Praziquantel. That is 0.5% of all reports for this medicine, compared with 1.8% across reports for all dog medicines, so it is reported less often than average with this medicine.

49Reports

96%Marked serious

22%Recovered

27%Died or euthanised

10 daysTypical onset

How soon it started

Same day

4 14%

1–2 days

5 17%

3–7 days

4 14%

1–4 weeks

9 31%

Over a month

7 24%

How the animals did

Recovered

11 22%

Still unwell when reported

15 31%

Died

5 10%

Euthanised

8 16%

Not known

10 20%

Problems reported at the same time

33 67%

21 43%

15 31%

14 29%

13 27%

12 24%

9 18%

8 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause blood problems in dogs?: 49 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 10 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood problems with similar medicines

Blood problems after Spinosad (Comfortis) 364 reports · 0.6% of its reports
Blood problems after Lufenuron + Milbemycin Oxime (Sentinel) 184 reports · 0.7% of its reports
Blood problems after Imidacloprid + Moxidectin (Advantage Multi) 88 reports · 0.7% of its reports
Blood problems after Nitenpyram (Capstar) 54 reports · 0.5% of its reports
Blood problems after Fipronil + S-methoprene (Frontline Plus) 23 reports · 0.8% of its reports
Blood problems after Flumethrin + Imidacloprid (Seresto) 28 reports · 1.2% of its reports
Blood problems after Fipronil 20 reports · 1.4% of its reports
Blood problems after Lufenuron 27 reports · 2.7% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with blood problems