Blood problems after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

The FDA has received 184 reports of blood problems in dogs after Lufenuron + Milbemycin Oxime. That is 0.7% of all reports for this medicine, compared with 1.8% across reports for all dog medicines, so it is reported less often than average with this medicine.

184Reports

55%Marked serious

15%Recovered

33%Died or euthanised

14 daysTypical onset

How soon it started

Same day

18 27%

1–2 days

5 7.6%

3–7 days

6 9.1%

1–4 weeks

13 20%

Over a month

24 36%

How the animals did

Recovered

25 14%

Recovered with lasting effects

2 1.1%

Still unwell when reported

30 16%

Died

36 20%

Euthanised

24 13%

Not known

67 36%

Problems reported at the same time

83 45%

69 38%

60 33%

51 28%

50 27%

39 21%

35 19%

28 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause blood problems in dogs?: 184 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 14 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood problems with similar medicines

Blood problems after Spinosad (Comfortis) 364 reports · 0.6% of its reports
Blood problems after Imidacloprid + Moxidectin (Advantage Multi) 88 reports · 0.7% of its reports
Blood problems after Nitenpyram (Capstar) 54 reports · 0.5% of its reports
Blood problems after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 49 reports · 0.5% of its reports
Blood problems after Fipronil + S-methoprene (Frontline Plus) 23 reports · 0.8% of its reports
Blood problems after Flumethrin + Imidacloprid (Seresto) 28 reports · 1.2% of its reports
Blood problems after Fipronil 20 reports · 1.4% of its reports
Blood problems after Lufenuron 27 reports · 2.7% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with blood problems