Fever after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

The FDA has received 178 reports of fever in dogs after Lufenuron + Milbemycin Oxime. That is 0.7% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

178Reports

39%Marked serious

19%Recovered

15%Died or euthanised

1 daysTypical onset

How soon it started

Same day

20 38%

1–2 days

17 32%

3–7 days

2 3.8%

1–4 weeks

8 15%

Over a month

6 11%

How the animals did

Recovered

32 18%

Recovered with lasting effects

1 0.6%

Still unwell when reported

23 13%

Died

21 12%

Euthanised

6 3.4%

Not known

95 53%

Problems reported at the same time

111 62%

84 47%

62 35%

50 28%

38 21%

29 16%

28 16%

26 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause fever in dogs?: 178 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Fever with similar medicines

Fever after Spinosad (Comfortis) 412 reports · 0.7% of its reports
Fever after Imidacloprid + Moxidectin (Advantage Multi) 165 reports · 1.3% of its reports
Fever after Nitenpyram (Capstar) 78 reports · 0.7% of its reports
Fever after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 35 reports · 0.4% of its reports
Fever after Fipronil + S-methoprene (Frontline Plus) 44 reports · 1.5% of its reports
Fever after Flumethrin + Imidacloprid (Seresto) 31 reports · 1.4% of its reports
Fever after Lufenuron 41 reports · 4.0% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with fever