Fever after Imidacloprid + Moxidectin (Advantage Multi) in dogs

165 reports to the FDA describe fever in dogs given Imidacloprid + Moxidectin. That is 1.3% of all reports for this medicine, compared with 1.4% across reports for all dog medicines.

165Reports

70%Marked serious

31%Recovered

13%Died or euthanised

1 daysTypical onset

How soon it started

Same day

38 36%

1–2 days

30 29%

3–7 days

19 18%

1–4 weeks

10 9.5%

Over a month

8 7.6%

How the animals did

Recovered

48 29%

Recovered with lasting effects

3 1.8%

Still unwell when reported

10 6.1%

Died

14 8.5%

Euthanised

8 4.8%

Not known

82 50%

Problems reported at the same time

68 41%

55 33%

52 32%

38 23%

35 21%

31 19%

26 16%

22 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause fever in dogs?: 165 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Fever with similar medicines

Fever after Spinosad (Comfortis) 412 reports · 0.7% of its reports
Fever after Lufenuron + Milbemycin Oxime (Sentinel) 178 reports · 0.7% of its reports
Fever after Nitenpyram (Capstar) 78 reports · 0.7% of its reports
Fever after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 35 reports · 0.4% of its reports
Fever after Fipronil + S-methoprene (Frontline Plus) 44 reports · 1.5% of its reports
Fever after Flumethrin + Imidacloprid (Seresto) 31 reports · 1.4% of its reports
Fever after Lufenuron 41 reports · 4.0% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with fever