Blood problems after Imidacloprid + Moxidectin (Advantage Multi) in dogs

88 reports to the FDA describe blood problems in dogs given Imidacloprid + Moxidectin. That is 0.7% of all reports for this medicine, compared with 1.8% across reports for all dog medicines, so it is reported less often than average with this medicine.

88Reports

78%Marked serious

25%Recovered

32%Died or euthanised

5 daysTypical onset

How soon it started

Same day

7 13%

1–2 days

15 28%

3–7 days

12 22%

1–4 weeks

8 15%

Over a month

12 22%

How the animals did

Recovered

22 25%

Still unwell when reported

5 5.7%

Died

13 15%

Euthanised

15 17%

Not known

33 38%

Problems reported at the same time

43 49%

31 35%

30 34%

28 32%

21 24%

18 20%

17 19%

15 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause blood problems in dogs?: 88 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 5 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood problems with similar medicines

Blood problems after Spinosad (Comfortis) 364 reports · 0.6% of its reports
Blood problems after Lufenuron + Milbemycin Oxime (Sentinel) 184 reports · 0.7% of its reports
Blood problems after Nitenpyram (Capstar) 54 reports · 0.5% of its reports
Blood problems after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 49 reports · 0.5% of its reports
Blood problems after Fipronil + S-methoprene (Frontline Plus) 23 reports · 0.8% of its reports
Blood problems after Flumethrin + Imidacloprid (Seresto) 28 reports · 1.2% of its reports
Blood problems after Fipronil 20 reports · 1.4% of its reports
Blood problems after Lufenuron 27 reports · 2.7% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with blood problems