Vomiting after Spinosad (Comfortis) in dogs

The FDA has received 30,909 reports of vomiting in dogs after Spinosad. That is 54% of all reports for this medicine, compared with 28% across reports for all dog medicines, so it is reported unusually often with this medicine.

30,909Reports

4.7%Marked serious

62%Recovered

1.3%Died or euthanised

Same dayTypical onset

How soon it started

Same day

10,379 61%

1–2 days

617 3.6%

3–7 days

206 1.2%

1–4 weeks

718 4.2%

Over a month

5,127 30%

How the animals did

Recovered

18,572 60%

Recovered with lasting effects

686 2.2%

Still unwell when reported

448 1.4%

Died

297 1.0%

Euthanised

99 0.3%

Not known

10,807 35%

Problems reported at the same time

3,321 11%

1,567 5.1%

1,428 4.6%

903 2.9%

746 2.4%

633 2.0%

608 2.0%

497 1.6%

Age of the animals

Under 1 year

3,505

1–3 years

11,277

4–7 years

8,377

8–11 years

4,085

12+ years

1,620

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause vomiting in dogs?: 30,909 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

Vomiting after Lufenuron + Milbemycin Oxime (Sentinel) 4,725 reports · 18% of its reports
Vomiting after Imidacloprid + Moxidectin (Advantage Multi) 1,904 reports · 15% of its reports
Vomiting after Nitenpyram (Capstar) 1,204 reports · 11% of its reports
Vomiting after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 1,925 reports · 19% of its reports
Vomiting after Fipronil + S-methoprene (Frontline Plus) 627 reports · 21% of its reports
Vomiting after Flumethrin + Imidacloprid (Seresto) 295 reports · 13% of its reports
Vomiting after Imidacloprid 251 reports · 13% of its reports
Vomiting after Fipronil 417 reports · 30% of its reports
Vomiting after Lufenuron 325 reports · 32% of its reports
Vomiting after Imidacloprid + Permethrin + Pyriproxyfen 116 reports · 16% of its reports

All reported side effects of Spinosad in dogs · Medicines most reported with vomiting