Loss of appetite after Spinosad (Comfortis) in dogs

The FDA has received 3,161 reports of loss of appetite in dogs after Spinosad. That is 5.5% of all reports for this medicine, compared with 8.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

3,161Reports
22%Marked serious
35%Recovered
9.6%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
669 44%
1–2 days
287 19%
3–7 days
64 4.2%
1–4 weeks
106 6.9%
Over a month
404 26%

How the animals did

Recovered
823 26%
Recovered with lasting effects
296 9.4%
Still unwell when reported
225 7.1%
Died
206 6.5%
Euthanised
96 3.0%
Not known
1,515 48%

Problems reported at the same time

1,962 62%
1,567 50%
532 17%
443 14%
293 9.3%

Age of the animals

Under 1 year
353
1–3 years
990
4–7 years
848
8–11 years
579
12+ years
290

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause loss of appetite in dogs?
3,161 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loss of appetite with similar medicines

All reported side effects of Spinosad in dogs · Medicines most reported with loss of appetite