Skin hyperaemia after Spinosad (Comfortis) in dogs

257 reports to the FDA describe skin hyperaemia in dogs given Spinosad. That is 0.5% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

257Reports

2.3%Marked serious

1.2%Recovered

1.2%Died or euthanised

–Typical onset

How the animals did

Recovered

2 0.8%

Recovered with lasting effects

1 0.4%

Still unwell when reported

3 1.2%

Died

3 1.2%

Not known

248 96%

Problems reported at the same time

Itching

122 47%

Skin rash or irritation

59 23%

49 19%

46 18%

44 17%

40 16%

29 11%

26 10%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause skin hyperaemia in dogs?: 257 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin hyperaemia with similar medicines

Skin hyperaemia after Lufenuron + Milbemycin Oxime (Sentinel) 80 reports · 0.3% of its reports
Skin hyperaemia after Imidacloprid + Moxidectin (Advantage Multi) 31 reports · 0.2% of its reports
Skin hyperaemia after Nitenpyram (Capstar) 41 reports · 0.4% of its reports
Skin hyperaemia after Lufenuron 56 reports · 5.5% of its reports

All reported side effects of Spinosad in dogs · Medicines most reported with skin hyperaemia