Diarrhea after Fipronil + Pyriproxyfen + S-methoprene in dogs

40 reports to the FDA describe diarrhea in dogs given Fipronil + Pyriproxyfen + S-methoprene. That is 9.3% of all reports for this medicine, compared with 8.4% across reports for all dog medicines.

40Reports

33%Marked serious

57%Recovered

0.0%Died or euthanised

28 daysTypical onset

How soon it started

Same day

4 14%

1–2 days

4 14%

3–7 days

1 3.6%

1–4 weeks

13 46%

Over a month

6 21%

How the animals did

Recovered

23 57%

Still unwell when reported

1 2.5%

Not known

16 40%

Problems reported at the same time

Vomiting

22 55%

Loss of appetite

12 30%

Lethargy

10 25%

Swelling

2 5.0%

Pancreatitis

2 5.0%

Itching

2 5.0%

Tremors

2 5.0%

Frequent urination

1 2.5%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fipronil kills fleas and ticks (spot-on).

Questions owners ask

Can Fipronil + Pyriproxyfen + S-methoprene cause diarrhea in dogs?: 40 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 28 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diarrhea with similar medicines

Diarrhea after Spinosad (Comfortis) 2,388 reports · 4.2% of its reports
Diarrhea after Lufenuron + Milbemycin Oxime (Sentinel) 2,524 reports · 9.7% of its reports
Diarrhea after Imidacloprid + Moxidectin (Advantage Multi) 1,203 reports · 9.2% of its reports
Diarrhea after Nitenpyram (Capstar) 626 reports · 5.8% of its reports
Diarrhea after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 800 reports · 8.0% of its reports
Diarrhea after Fipronil + S-methoprene (Frontline Plus) 230 reports · 7.8% of its reports
Diarrhea after Flumethrin + Imidacloprid (Seresto) 130 reports · 5.7% of its reports
Diarrhea after Imidacloprid 93 reports · 4.9% of its reports
Diarrhea after Fipronil 123 reports · 8.7% of its reports
Diarrhea after Lufenuron 182 reports · 18% of its reports

All reported side effects of Fipronil + Pyriproxyfen + S-methoprene in dogs · Medicines most reported with diarrhea